What the FDA labels say about taking them together
Alprazolam and itraconazole
Alprazolam's FDA label of January 18, 2023 names itraconazole in its contraindications section, and itraconazole's label names alprazolam too. The alprazolam label: “• taking strong cytochrome P450 3A (CYP3A) inhibitors, except ritonavir Known hypersensitivity to alprazolam or other benzodiazepines.”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the alprazolam label say about itraconazole?
Alprazolam label, contraindications• taking strong cytochrome P450 3A (CYP3A) inhibitors (e.g., ketoconazole, itraconazole), except ritonavir [see Dosage and Administration (2.6), Warnings and Precautions (5.5), Drug Interactions (7.1) ] Known hypersensitivity to alprazolam or other benzodiazepines.
Alprazolam label, drug interactionsExamples; Ketoconazole, itraconazole, clarithromycin
Alprazolam label, warnings and precautionsKetoconazole and itraconazole have been shown in vivo to increase plasma alprazolam concentrations 3.98 fold and 2.70 fold, respectively.
Alprazolam Xr label (Mylan Pharmaceuticals Inc., February 11, 2025), contraindications• taking strong cytochrome P450 3A (CYP3A) inhibitors (e.g., ketoconazole, itraconazole), except ritonavir [see Dosage and Administration (2.5), Warnings and Precautions (5.5), Drug Interactions (7.1) ]. Known hypersensitivity to alprazolam or other benzodiazepines.
Source: FDA drug label (Alprazolam Xr, NDA021434), Mylan Pharmaceuticals Inc., effective February 11, 2025 (SPL set 1338d1c9-7c75-42ed-95f3-9eb1b6fc51d3), via openFDA
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the itraconazole label say about alprazolam?
Itraconazole label, drug interactionsAntipsychotics, Anxiolytics and Hypnotics Alprazolam Aripiprazole Buspirone Cariprazine Diazepam Haloperidol Midazolam (IV) Quetiapine Ramelteon Risperidone Suvorexant Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Itraconazole | |
|---|---|---|
| Labeled for | Anxiety | Fungal infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once