Alprazolam and Itraconazole Interaction
Drug interaction information between Alprazolam and Itraconazole.
Alprazolam and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alprazolam and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole slows the breakdown of alprazolam in the body, which can increase the amount of medicine in your blood.
FDA Label Information
Examples Ketoconazole, itraconazole, clarithromycin Moderate or Weak Inhibitors of CYP3A Clinical implication Concomitant use of alprazolam with CYP3A inhibitors may increase the concentrations of alprazolam, resulting in increased risk of adverse reactions of alprazolam [see Clinical Pharmacology (12.3) ].
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Digoxin moderate
- Aprepitant moderate
- Fluoxetine moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Alprazolam + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Alprazolam's 27. In the moderate band specifically: Alprazolam has 7 (also Ketoconazole, Clarithromycin, Digoxin, Aprepitant); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Alprazolam and Itraconazole?
Itraconazole slows the breakdown of alprazolam in the body, which can increase the amount of medicine in your blood.
Itraconazole carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is moderate · classes on file: Alprazolam (Benzodiazepine); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Alprazolam's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 20 minor · 27 total
- Other moderate peers for Alprazolam
- Ketoconazole
- Clarithromycin
- Digoxin
- Aprepitant
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.