Alprazolam and Itraconazole Interaction
Drug interaction information between Alprazolam and Itraconazole.
Alprazolam and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alprazolam and Itraconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Itraconazole slows the breakdown of alprazolam in the body, which can increase the amount of medicine in your blood.
What To Do
Use these medications together with caution and notify your doctor if you feel overly tired or dizzy.
FDA Label Information
Examples Ketoconazole, itraconazole, clarithromycin Moderate or Weak Inhibitors of CYP3A Clinical implication Concomitant use of alprazolam with CYP3A inhibitors may increase the concentrations of alprazolam, resulting in increased risk of adverse reactions of alprazolam [see Clinical Pharmacology (12.3) ].
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Digoxin moderate
- Aprepitant moderate
- Fluoxetine moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
Can I take Alprazolam and Itraconazole together?
This is a moderate interaction. Use these medications together with caution and notify your doctor if you feel overly tired or dizzy.
How serious is the interaction between Alprazolam and Itraconazole?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Alprazolam and Itraconazole interact?
Itraconazole slows the breakdown of alprazolam in the body, which can increase the amount of medicine in your blood.
Understanding the Alprazolam and Itraconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Alprazolam belongs to the Benzodiazepine class and Itraconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Itraconazole slows the breakdown of alprazolam in the body, which can increase the amount of medicine in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Alprazolam has 27 total documented interactions on file in this dataset, and Itraconazole has 116. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use these medications together with caution and notify your doctor if you feel overly tired or dizzy. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Alprazolam or Itraconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.