Alprazolam and Digoxin Interaction
Drug interaction information between Alprazolam and Digoxin.
Alprazolam and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alprazolam and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Alprazolam can cause digoxin levels to build up in the body, which can lead to dangerous side effects. This happens more often in patients over the age of 65.
FDA Label Information
( 7.1 ) Use with Digoxin: Increase the risk of digoxin toxicity. Digoxin Clinical implication Increased digoxin concentrations have been reported when alprazolam was given, especially in geriatric patients (>65 years of age). Prevention or management In patients on digoxin therapy, measure serum digoxin concentrations before initiating alprazolam.
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Aprepitant moderate
- Fluoxetine moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Alprazolam + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Alprazolam's 27. In the moderate band specifically: Alprazolam has 7 (also Ketoconazole, Clarithromycin, Itraconazole, Aprepitant); Digoxin has 13 (also Sotalol, Dofetilide, Ivabradine, Dopamine).
What mechanism field is on file for Alprazolam and Digoxin?
Alprazolam can cause digoxin levels to build up in the body, which can lead to dangerous side effects. This happens more often in patients over the age of 65.
Digoxin carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is moderate · classes on file: Alprazolam (Benzodiazepine); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Alprazolam's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 20 minor · 27 total
- Other moderate peers for Alprazolam
- Ketoconazole
- Clarithromycin
- Itraconazole
- Aprepitant
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Ivabradine
- Dopamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.