What the FDA labels say about taking them together
Alprazolam and clarithromycin
Alprazolam's FDA label of January 18, 2023 names clarithromycin in its drug interactions section, and clarithromycin's label names alprazolam too. The clarithromycin label: “Alprazolam Triazolam Triazolam, Alprazolam: Caution and appropriate dose adjustments should be considered when triazolam or alprazolam is co-administered with clarithromycin.”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation).
What does the alprazolam label say about clarithromycin?
Alprazolam label, drug interactionsExamples; Ketoconazole, itraconazole, clarithromycin
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the clarithromycin label say about alprazolam?
Clarithromycin label, drug interactionsAlprazolam Triazolam Triazolam, Alprazolam: Caution and appropriate dose adjustments should be considered when triazolam or alprazolam is co-administered with clarithromycin.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Clarithromycin | |
|---|---|---|
| Labeled for | Anxiety | Bacterial infections, Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | $0.466 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once