Alprazolam and Clarithromycin Interaction
Drug interaction information between Alprazolam and Clarithromycin.
Alprazolam and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alprazolam and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin interferes with the liver's ability to clear alprazolam, which may make the alprazolam stay in your system longer.
FDA Label Information
Examples Ketoconazole, itraconazole, clarithromycin Moderate or Weak Inhibitors of CYP3A Clinical implication Concomitant use of alprazolam with CYP3A inhibitors may increase the concentrations of alprazolam, resulting in increased risk of adverse reactions of alprazolam [see Clinical Pharmacology (12.3) ].
Alprazolam Also Interacts With
- Ketoconazole moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
- Fluoxetine moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Alprazolam + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Alprazolam's 27. In the moderate band specifically: Alprazolam has 7 (also Ketoconazole, Itraconazole, Digoxin, Aprepitant); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Alprazolam and Clarithromycin?
Clarithromycin interferes with the liver's ability to clear alprazolam, which may make the alprazolam stay in your system longer.
Clarithromycin carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is moderate · classes on file: Alprazolam (Benzodiazepine); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Alprazolam's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 20 minor · 27 total
- Other moderate peers for Alprazolam
- Ketoconazole
- Itraconazole
- Digoxin
- Aprepitant
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.