Alprazolam and Aprepitant Interaction
Drug interaction information between Alprazolam and Aprepitant.
Alprazolam and Aprepitant have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alprazolam and Aprepitant. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aprepitant slows down how fast your body processes alprazolam, which causes the drug to build up in your blood. This can make you feel much more sleepy or dizzy than usual.
FDA Label Information
Benzodiazepines Clinical Impact Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions [see Clinical Pharmacology ( 12.3 )]. Benzodiazepines Clinical Impact Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions [see Clinical Pharmacology ( 12.3 )].
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Fluoxetine moderate
Aprepitant Also Interacts With
- Pimozide major
- Diltiazem moderate
- Methylprednisolone moderate
- Ketoconazole moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Alprazolam + Aprepitant?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Alprazolam has 27 labeled pairs on file vs Aprepitant's 22. In the moderate band specifically: Alprazolam has 7 (also Ketoconazole, Clarithromycin, Itraconazole, Digoxin); Aprepitant has 9 (also Diltiazem, Methylprednisolone, Ketoconazole, Clarithromycin).
What mechanism field is on file for Alprazolam and Aprepitant?
Aprepitant slows down how fast your body processes alprazolam, which causes the drug to build up in your blood. This can make you feel much more sleepy or dizzy than usual.
Aprepitant carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is moderate · classes on file: Alprazolam (Benzodiazepine); Aprepitant (NK1 Receptor Antagonist (Antiemetic)).
Aprepitant has 1 major-labeled pair vs Alprazolam's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 20 minor · 27 total
- Other moderate peers for Alprazolam
- Ketoconazole
- Clarithromycin
- Itraconazole
- Digoxin
1 major · 9 moderate · 12 minor · 22 total
- Other moderate peers for Aprepitant
- Diltiazem
- Methylprednisolone
- Ketoconazole
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.