Alprazolam and Oxycodone Interaction
Drug interaction information between Alprazolam and Oxycodone.
Alprazolam and Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alprazolam and Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs have a combined effect that can severely slow down your breathing and brain activity.
FDA Label Information
Examples Morphine, buprenorphine, hydromorphone, oxymorphone, oxycodone, fentanyl, methadone, alfentanil, butorpenol, codeine, dihydrocodeine, meperidine, pentazocine, remifentanil, sufentanil, tapentadol, tramadol.
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Frequently Asked Questions
What SPL severity band is on file for Alprazolam + Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Oxycodone has 28 labeled pairs on file vs Alprazolam's 27. In the minor band specifically: Alprazolam has 20 (also Tramadol, Morphine, Carbamazepine, Erythromycin); Oxycodone has 22 (also Trazodone, Tramadol, Cyclobenzaprine, Pregabalin).
What mechanism field is on file for Alprazolam and Oxycodone?
These drugs have a combined effect that can severely slow down your breathing and brain activity.
Oxycodone's labeled portfolio outnumbers Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Alprazolam (Benzodiazepine); Oxycodone (Opioid Analgesic).
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Morphine
- Carbamazepine
- Erythromycin
0 major · 6 moderate · 22 minor · 28 total
- Other minor peers for Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.