Alprazolam and Tramadol Interaction
Drug interaction information between Alprazolam and Tramadol.
Alprazolam and Tramadol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alprazolam and Tramadol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down the nervous system, which can cause dangerous sleepiness or breathing problems.
FDA Label Information
Examples Morphine, buprenorphine, hydromorphone, oxymorphone, oxycodone, fentanyl, methadone, alfentanil, butorpenol, codeine, dihydrocodeine, meperidine, pentazocine, remifentanil, sufentanil, tapentadol, tramadol.
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Tramadol Also Interacts With
- Safinamide major
- Carbamazepine moderate
- Rifampin moderate
- Phenytoin moderate
- Gabapentin minor
Frequently Asked Questions
What SPL severity band is on file for Alprazolam + Tramadol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tramadol has 38 labeled pairs on file vs Alprazolam's 27. In the minor band specifically: Alprazolam has 20 (also Oxycodone, Morphine, Carbamazepine, Erythromycin); Tramadol has 34 (also Gabapentin, Bupropion, Fluoxetine, Cyclobenzaprine).
What mechanism field is on file for Alprazolam and Tramadol?
Both drugs slow down the nervous system, which can cause dangerous sleepiness or breathing problems.
Tramadol carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Alprazolam (Benzodiazepine); Tramadol (Opioid Analgesic).
Tramadol has 1 major-labeled pair vs Alprazolam's 0. This page itself is in the minor band, not the major band.
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Oxycodone
- Morphine
- Carbamazepine
- Erythromycin
1 major · 3 moderate · 34 minor · 38 total
- Other minor peers for Tramadol
- Gabapentin
- Bupropion
- Fluoxetine
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.