Alprazolam and Morphine Interaction
Drug interaction information between Alprazolam and Morphine.
Alprazolam and Morphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alprazolam and Morphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down the brain and breathing. Taking them together can cause extreme sleepiness or dangerous breathing problems.
FDA Label Information
Examples Morphine, buprenorphine, hydromorphone, oxymorphone, oxycodone, fentanyl, methadone, alfentanil, butorpenol, codeine, dihydrocodeine, meperidine, pentazocine, remifentanil, sufentanil, tapentadol, tramadol.
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Morphine Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Alprazolam + Morphine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Morphine has 30 labeled pairs on file vs Alprazolam's 27. In the minor band specifically: Alprazolam has 20 (also Tramadol, Oxycodone, Carbamazepine, Erythromycin); Morphine has 30 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine).
What mechanism field is on file for Alprazolam and Morphine?
Both drugs slow down the brain and breathing. Taking them together can cause extreme sleepiness or dangerous breathing problems.
Morphine's labeled portfolio outnumbers Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Alprazolam (Benzodiazepine); Morphine (Opioid Analgesic).
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Carbamazepine
- Erythromycin
0 major · 0 moderate · 30 minor · 30 total
- Other minor peers for Morphine
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.