Furosemide and Norepinephrine Interaction
Drug interaction information between Furosemide and Norepinephrine.
Furosemide and Norepinephrine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Furosemide and Norepinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The water pill can make your blood vessels less sensitive to the effects of the blood pressure medicine.
FDA Label Information
Furosemide may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively.
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Furosemide + Norepinephrine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Furosemide's 36. In the minor band specifically: Furosemide has 29 (also Methotrexate, Ethacrynic Acid, Indomethacin, Sucralfate); Norepinephrine has 42 (also Amitriptyline, Linezolid, Nortriptyline, Desipramine).
What mechanism field is on file for Furosemide and Norepinephrine?
The water pill can make your blood vessels less sensitive to the effects of the blood pressure medicine.
Furosemide carries more major-labeled pairs than Norepinephrine
SPL source-record counts only. This page's band is minor · classes on file: Furosemide (Loop Diuretic); Norepinephrine (Vasopressor (Alpha-1 Agonist)).
Furosemide has 3 major-labeled pairs vs Norepinephrine's 1. This page itself is in the minor band, not the major band.
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Ethacrynic Acid
- Indomethacin
- Sucralfate
1 major · 7 moderate · 42 minor · 50 total
- Other minor peers for Norepinephrine
- Amitriptyline
- Linezolid
- Nortriptyline
- Desipramine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.