Furosemide and Indomethacin Interaction
Drug interaction information between Furosemide and Indomethacin.
Furosemide and Indomethacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Furosemide and Indomethacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Indomethacin blocks natural chemicals that help the water pill remove salt and lower blood pressure.
FDA Label Information
Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and furosemide should be observed closely to determine if the desired diuretic and/or antihypertensive effect of furosemide is achieved.
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Furosemide + Indomethacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Indomethacin's 35. In the minor band specifically: Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Sucralfate); Indomethacin has 30 (also Meloxicam, Aspirin, Diclofenac, Cyclosporine).
What mechanism field is on file for Furosemide and Indomethacin?
Indomethacin blocks natural chemicals that help the water pill remove salt and lower blood pressure.
Furosemide carries more major-labeled pairs than Indomethacin
SPL source-record counts only. This page's band is minor · classes on file: Furosemide (Loop Diuretic); Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Furosemide has 3 major-labeled pairs vs Indomethacin's 0. This page itself is in the minor band, not the major band.
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Sucralfate
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Diclofenac
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.