Furosemide and Sucralfate Interaction
Drug interaction information between Furosemide and Sucralfate.
Furosemide and Sucralfate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Furosemide and Sucralfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sucralfate can prevent the body from absorbing furosemide correctly when they are taken at the same time. This makes the furosemide less effective at lowering blood pressure and removing extra fluid.
FDA Label Information
Simultaneous administration of sucralfate and furosemide tablets may reduce the natriuretic and antihypertensive effects of furosemide. The intake of furosemide and sucralfate should be separated by at least two hours.
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ketoconazole minor
- Ciprofloxacin minor
Frequently Asked Questions
What SPL severity band is on file for Furosemide + Sucralfate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Sucralfate's 20. In the minor band specifically: Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin); Sucralfate has 18 (also Warfarin, Ketoconazole, Ciprofloxacin, Ofloxacin).
What mechanism field is on file for Furosemide and Sucralfate?
Sucralfate can prevent the body from absorbing furosemide correctly when they are taken at the same time. This makes the furosemide less effective at lowering blood pressure and removing extra fluid.
Furosemide carries more major-labeled pairs than Sucralfate
SPL source-record counts only. This page's band is minor · classes on file: Furosemide (Loop Diuretic); Sucralfate (Mucosal Protective Agent).
Furosemide has 3 major-labeled pairs vs Sucralfate's 1. This page itself is in the minor band, not the major band.
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Warfarin
- Ketoconazole
- Ciprofloxacin
- Ofloxacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.