Norepinephrine and Deutetrabenazine Interaction
Drug interaction information between Norepinephrine and Deutetrabenazine.
Norepinephrine and Deutetrabenazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Norepinephrine and Deutetrabenazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication can lower the levels of norepinephrine in your brain. Taking it when levels are already low could cause a severe and dangerous drop in this important chemical.
FDA Label Information
Prescribers should wait for chorea or dyskinesia to reemerge before administering AUSTEDO XR or AUSTEDO to help reduce the risk of overdosage and major depletion of serotonin and norepinephrine in the central nervous system.
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Digoxin moderate
- Edoxaban moderate
Deutetrabenazine Also Interacts With
- Valbenazine major
- Tetrabenazine major
- Dopamine moderate
- Bupropion minor
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Deutetrabenazine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Deutetrabenazine's 7. In the moderate band specifically: Norepinephrine has 7 (also Carbidopa/Levodopa, Clopidogrel, Digoxin, Edoxaban); Deutetrabenazine has 2 (also Dopamine).
What mechanism field is on file for Norepinephrine and Deutetrabenazine?
This medication can lower the levels of norepinephrine in your brain. Taking it when levels are already low could cause a severe and dangerous drop in this important chemical.
Deutetrabenazine carries more major-labeled pairs than Norepinephrine
SPL source-record counts only. This page's band is moderate · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Deutetrabenazine (VMAT2 Inhibitor).
Deutetrabenazine has 2 major-labeled pairs vs Norepinephrine's 1. This page itself is in the moderate band, not the major band.
1 major · 7 moderate · 42 minor · 50 total
- Other moderate peers for Norepinephrine
- Carbidopa/Levodopa
- Clopidogrel
- Digoxin
- Edoxaban
2 major · 2 moderate · 3 minor · 7 total
- Other moderate peers for Deutetrabenazine
- Dopamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.