Norepinephrine and Nortriptyline Interaction
Drug interaction information between Norepinephrine and Nortriptyline.
Norepinephrine and Nortriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Norepinephrine and Nortriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nortriptyline stops the body from clearing norepinephrine, which causes it to build up and raise blood pressure.
FDA Label Information
7.2 Tricyclic Antidepressants Co-administration of norepinephrine bitartrate with tricyclic antidepressants (including amitriptyline, nortriptyline, protriptyline, clomipramine, desipramine, imipramine) can cause severe, prolonged hypertension.
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Nortriptyline Also Interacts With
- Bupropion minor
- Carbamazepine minor
- Darunavir minor
- Dopamine minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Nortriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Nortriptyline's 8. In the minor band specifically: Norepinephrine has 42 (also Amitriptyline, Linezolid, Desipramine, Clomipramine); Nortriptyline has 8 (also Bupropion, Carbamazepine, Darunavir, Dopamine).
What mechanism field is on file for Norepinephrine and Nortriptyline?
Nortriptyline stops the body from clearing norepinephrine, which causes it to build up and raise blood pressure.
Norepinephrine carries more major-labeled pairs than Nortriptyline
SPL source-record counts only. This page's band is minor · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Nortriptyline (Tricyclic Antidepressant (TCA)).
Norepinephrine has 1 major-labeled pair vs Nortriptyline's 0. This page itself is in the minor band, not the major band.
1 major · 7 moderate · 42 minor · 50 total
- Other minor peers for Norepinephrine
- Amitriptyline
- Linezolid
- Desipramine
- Clomipramine
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Nortriptyline
- Bupropion
- Carbamazepine
- Darunavir
- Dopamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.