Furosemide and Lithium Interaction
Drug interaction information between Furosemide and Lithium.
Furosemide and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Furosemide and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Furosemide prevents the kidneys from clearing lithium out of the body properly. This causes lithium to build up to dangerous levels, which can lead to toxicity.
FDA Label Information
Lithium generally should not be given with diuretics because they reduce lithium's renal clearance and add a high risk of lithium toxicity.
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Oxaprozin moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Furosemide + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Furosemide's 36. In the moderate band specifically: Furosemide has 4 (also Cyclosporine, Oxaprozin, Piroxicam); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Furosemide and Lithium?
Furosemide prevents the kidneys from clearing lithium out of the body properly. This causes lithium to build up to dangerous levels, which can lead to toxicity.
Furosemide carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is moderate · classes on file: Furosemide (Loop Diuretic); Lithium (Mood Stabilizer).
Furosemide has 3 major-labeled pairs vs Lithium's 2. This page itself is in the moderate band, not the major band.
3 major · 4 moderate · 29 minor · 36 total
- Other moderate peers for Furosemide
- Cyclosporine
- Oxaprozin
- Piroxicam
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.