What the FDA labels say about taking them together
Furosemide and lithium
Furosemide's FDA label of September 30, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name furosemide. The furosemide label: “Risk of ototoxicity and nephrotoxicity Lithium: Risk of lithium toxicity Renin-angiotensin inhibitors:”
Check it at the source: the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the furosemide label say about lithium?
Furosemide label, drug interactionsLithium generally should not be given with diuretics because they reduce lithium’s renal clearance and add a high risk of lithium toxicity.
Furosemide label (Hikma Pharmaceuticals USA Inc., March 10, 2025), drug interactionsRisk of ototoxicity and nephrotoxicity ( 7.1 ) Lithium: Risk of lithium toxicity ( 7.1 ) Renin-angiotensin inhibitors:
Source: FDA drug label (Furosemide, NDA018267), Hikma Pharmaceuticals USA Inc., effective March 10, 2025 (SPL set ddfc41a9-37d4-49c1-bbf3-969a98cd649c), via openFDA
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
What does the lithium label say about furosemide?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name furosemide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Furosemide | Lithium | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.490 per mL 20 mg/2 mL vial | $0.104 per capsule 300 mg capsule |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once