What the FDA labels say about taking them together
Furosemide and methotrexate
Furosemide's FDA label of September 30, 2025 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name furosemide. The furosemide label: “Methotrexate and other drugs that, like LASIX, undergo significant renal tubular secretion may reduce the effect of LASIX.”
Check it at the source: the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the furosemide label say about methotrexate?
Furosemide label, drug interactionsMethotrexate and other drugs that, like LASIX, undergo significant renal tubular secretion may reduce the effect of LASIX.
Furosemide label (Hikma Pharmaceuticals USA Inc., March 10, 2025), drug interactionsMethotrexate and other drugs undergoing renal tubular secretion Furosemide may decrease renal elimination of other drugs that undergo tubular secretion.
Source: FDA drug label (Furosemide, NDA018267), Hikma Pharmaceuticals USA Inc., effective March 10, 2025 (SPL set ddfc41a9-37d4-49c1-bbf3-969a98cd649c), via openFDA
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
What does the methotrexate label say about furosemide?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name furosemide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Furosemide | Methotrexate | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.490 per mL 20 mg/2 mL vial | $0.158 per tablet 2.5 mg tablet |
| Shortage now | In shortage | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once