Furosemide and Methotrexate Interaction
Drug interaction information between Furosemide and Methotrexate.
Furosemide and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Furosemide and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs leave the body through the same path in the kidneys, which can make the water pill work less effectively.
FDA Label Information
Methotrexate and other drugs that, like furosemide, undergo significant renal tubular secretion may reduce the effect of furosemide.
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Furosemide + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Furosemide's 36. In the minor band specifically: Furosemide has 29 (also Norepinephrine, Ethacrynic Acid, Indomethacin, Sucralfate); Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Furosemide and Methotrexate?
Both drugs leave the body through the same path in the kidneys, which can make the water pill work less effectively.
Furosemide carries more major-labeled pairs than Methotrexate
SPL source-record counts only. This page's band is minor · classes on file: Furosemide (Loop Diuretic); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
Furosemide has 3 major-labeled pairs vs Methotrexate's 0. This page itself is in the minor band, not the major band.
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
- Sucralfate
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.