Norepinephrine and Amitriptyline Interaction
Drug interaction information between Norepinephrine and Amitriptyline.
Norepinephrine and Amitriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Norepinephrine and Amitriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amitriptyline can interfere with how your body handles norepinephrine. This can cause your blood pressure to rise to a very high level and stay that way for a long time.
FDA Label Information
7.2 Tricyclic Antidepressants Co-administration of norepinephrine bitartrate with tricyclic antidepressants (including amitriptyline, nortriptyline, protriptyline, clomipramine, desipramine, imipramine) can cause severe, prolonged hypertension.
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Disulfiram minor
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Amitriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Amitriptyline's 21. In the minor band specifically: Norepinephrine has 42 (also Linezolid, Nortriptyline, Desipramine, Clomipramine); Amitriptyline has 20 (also Sertraline, Fluoxetine, Paroxetine, Disulfiram).
What mechanism field is on file for Norepinephrine and Amitriptyline?
Amitriptyline can interfere with how your body handles norepinephrine. This can cause your blood pressure to rise to a very high level and stay that way for a long time.
Norepinephrine's labeled portfolio outnumbers Amitriptyline
SPL source-record counts only. This page's band is minor · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Amitriptyline (Tricyclic Antidepressant (TCA)).
1 major · 7 moderate · 42 minor · 50 total
- Other minor peers for Norepinephrine
- Linezolid
- Nortriptyline
- Desipramine
- Clomipramine
1 major · 0 moderate · 20 minor · 21 total
- Other minor peers for Amitriptyline
- Sertraline
- Fluoxetine
- Paroxetine
- Disulfiram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.