Norepinephrine and Clopidogrel Interaction
Drug interaction information between Norepinephrine and Clopidogrel.
Norepinephrine and Clopidogrel have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Norepinephrine and Clopidogrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications affect how your blood cells, called platelets, stick together to form clots. Taking them at the same time can make it harder for your blood to clot, which raises the risk of bleeding.
FDA Label Information
( 7.3 ) Nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, selective serotonin and serotonin norepinephrine reuptake inhibitors (SSRIs, SNRIs): Increases risk of bleeding. 7.6 SSRIs and SNRIs Since selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) affect platelet activation, the concomitant administration of SSRIs and SNRIs with clopidogrel may increase the risk of bleeding.
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Deutetrabenazine moderate
- Digoxin moderate
- Edoxaban moderate
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Clopidogrel?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Clopidogrel's 19. In the moderate band specifically: Norepinephrine has 7 (also Carbidopa/Levodopa, Deutetrabenazine, Digoxin, Edoxaban); Clopidogrel has 9 (also Omeprazole, Warfarin, Esomeprazole, Rifampin).
What mechanism field is on file for Norepinephrine and Clopidogrel?
Both of these medications affect how your blood cells, called platelets, stick together to form clots. Taking them at the same time can make it harder for your blood to clot, which raises the risk of bleeding.
Norepinephrine carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is moderate · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Clopidogrel (Antiplatelet Agent).
Norepinephrine has 1 major-labeled pair vs Clopidogrel's 0. This page itself is in the moderate band, not the major band.
1 major · 7 moderate · 42 minor · 50 total
- Other moderate peers for Norepinephrine
- Carbidopa/Levodopa
- Deutetrabenazine
- Digoxin
- Edoxaban
0 major · 9 moderate · 10 minor · 19 total
- Other moderate peers for Clopidogrel
- Omeprazole
- Warfarin
- Esomeprazole
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.