What the FDA labels say about taking them together
Ethacrynic acid and furosemide
Furosemide's FDA label of September 30, 2025 names ethacrynic acid in its drug interactions section; the ethacrynic acid label PlainMeds reads does not name furosemide. The furosemide label: “Avoid combination Ethacrynic acid: Risk of ototoxicity.”
Check it at the source: the ethacrynic acid FDA label on DailyMed (effective August 31, 2020, Bausch Health US, LLC); the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC).
What does the ethacrynic acid label say about furosemide?
Ethacrynic acid's label (effective August 31, 2020) does not name furosemide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (EDECRIN), Bausch Health US, LLC, effective August 31, 2020 (SPL set 1efe378e-fee1-4ae9-8ea5-0fe2265fe2d8), via openFDA; the full label on DailyMed
What does the furosemide label say about ethacrynic acid?
Furosemide label, drug interactionsLASIX should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.
Furosemide label, warningsReports usually indicate that LASIX ototoxicity is associated with rapid injection, severe renal impairment, the use of higher than recommended doses, hypoproteinemia or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs.
Furosemide label (Hikma Pharmaceuticals USA Inc., March 10, 2025), drug interactionsAvoid combination ( 7.1 ) Ethacrynic acid: Risk of ototoxicity.
Source: FDA drug label (Furosemide, NDA018267), Hikma Pharmaceuticals USA Inc., effective March 10, 2025 (SPL set ddfc41a9-37d4-49c1-bbf3-969a98cd649c), via openFDA
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethacrynic acid | Furosemide | |
|---|---|---|
| Labeled for | Edema (fluid retention), Heart failure | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.807 per tablet 25 mg tablet | $0.490 per mL 20 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once