Norepinephrine and Linezolid Interaction
Drug interaction information between Norepinephrine and Linezolid.
Norepinephrine and Linezolid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Norepinephrine and Linezolid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid blocks the enzymes that normally break down norepinephrine in your body. This can cause a severe and long-lasting increase in your blood pressure.
FDA Label Information
( 7.4 ) 7.1 MAO-Inhibiting Drugs Co-administration of norepinephrine bitartrate with monoamine oxidase (MAO) inhibitors or other drugs with MAO-inhibiting properties (e.g., linezolid) can cause severe, prolonged hypertension.
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Linezolid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Linezolid's 29. In the minor band specifically: Norepinephrine has 42 (also Amitriptyline, Nortriptyline, Desipramine, Clomipramine); Linezolid has 18 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Norepinephrine and Linezolid?
Linezolid blocks the enzymes that normally break down norepinephrine in your body. This can cause a severe and long-lasting increase in your blood pressure.
Linezolid carries more major-labeled pairs than Norepinephrine
SPL source-record counts only. This page's band is minor · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Linezolid (Oxazolidinone Antibiotic).
Linezolid has 8 major-labeled pairs vs Norepinephrine's 1. This page itself is in the minor band, not the major band.
1 major · 7 moderate · 42 minor · 50 total
- Other minor peers for Norepinephrine
- Amitriptyline
- Nortriptyline
- Desipramine
- Clomipramine
8 major · 3 moderate · 18 minor · 29 total
- Other minor peers for Linezolid
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.