Norepinephrine and Digoxin Interaction
Drug interaction information between Norepinephrine and Digoxin.
Norepinephrine and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Norepinephrine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both stimulate the heart, which can lead to a higher risk of irregular heartbeats when used at the same time.
FDA Label Information
Sympathomimetics Epinephrine Norepinephrine Dopamine Can increase the risk of cardiac arrhythmias Neuromuscular Blocking Agents Succinylcholine May cause sudden extrusion of potassium from muscle cells causing arrhythmias in patients taking digoxin.
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Edoxaban moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Norepinephrine's 50. In the moderate band specifically: Norepinephrine has 7 (also Carbidopa/Levodopa, Clopidogrel, Deutetrabenazine, Edoxaban); Digoxin has 13 (also Sotalol, Dofetilide, Ivabradine, Dopamine).
What mechanism field is on file for Norepinephrine and Digoxin?
These medications both stimulate the heart, which can lead to a higher risk of irregular heartbeats when used at the same time.
Digoxin carries more major-labeled pairs than Norepinephrine
SPL source-record counts only. This page's band is moderate · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Norepinephrine's 1. This page itself is in the moderate band, not the major band.
1 major · 7 moderate · 42 minor · 50 total
- Other moderate peers for Norepinephrine
- Carbidopa/Levodopa
- Clopidogrel
- Deutetrabenazine
- Edoxaban
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Ivabradine
- Dopamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.