Norepinephrine and Desipramine Interaction
Drug interaction information between Norepinephrine and Desipramine.
Norepinephrine and Desipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Norepinephrine and Desipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Desipramine makes the effects of norepinephrine stronger and last longer, which can lead to very high blood pressure.
FDA Label Information
7.2 Tricyclic Antidepressants Co-administration of norepinephrine bitartrate with tricyclic antidepressants (including amitriptyline, nortriptyline, protriptyline, clomipramine, desipramine, imipramine) can cause severe, prolonged hypertension.
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Desipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Desipramine's 18. In the minor band specifically: Norepinephrine has 42 (also Amitriptyline, Linezolid, Nortriptyline, Clomipramine); Desipramine has 18 (also Atomoxetine, Bupropion, Darunavir, Desvenlafaxine).
What mechanism field is on file for Norepinephrine and Desipramine?
Desipramine makes the effects of norepinephrine stronger and last longer, which can lead to very high blood pressure.
Norepinephrine carries more major-labeled pairs than Desipramine
SPL source-record counts only. This page's band is minor · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Desipramine (Tricyclic Antidepressant (TCA)).
Norepinephrine has 1 major-labeled pair vs Desipramine's 0. This page itself is in the minor band, not the major band.
1 major · 7 moderate · 42 minor · 50 total
- Other minor peers for Norepinephrine
- Amitriptyline
- Linezolid
- Nortriptyline
- Clomipramine
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Darunavir
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.