Norepinephrine and Tranylcypromine Interaction
Drug interaction information between Norepinephrine and Tranylcypromine.
Norepinephrine and Tranylcypromine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Norepinephrine and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination stops the body from clearing norepinephrine, which can cause blood pressure to rise to levels that may cause a stroke or heart attack.
FDA Label Information
Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone,...
Norepinephrine Also Interacts With
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
- Edoxaban moderate
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Phenylephrine major
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Tranylcypromine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Tranylcypromine's 42. In the major band specifically: Norepinephrine has 1; Tranylcypromine has 7 (also Bupropion, Linezolid, Vilazodone, Epinephrine).
What mechanism field is on file for Norepinephrine and Tranylcypromine?
This combination stops the body from clearing norepinephrine, which can cause blood pressure to rise to levels that may cause a stroke or heart attack.
Tranylcypromine carries more major-labeled pairs than Norepinephrine
SPL source-record counts only. This page's band is major · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Norepinephrine's 1.
1 major · 7 moderate · 42 minor · 50 total
Norepinephrine has no other major-band peer in this dataset besides Tranylcypromine.
7 major · 23 moderate · 12 minor · 42 total
- Other major peers for Tranylcypromine
- Bupropion
- Linezolid
- Vilazodone
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.