Norepinephrine and Tranylcypromine Interaction
Drug interaction information between Norepinephrine and Tranylcypromine.
Norepinephrine and Tranylcypromine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Norepinephrine and Tranylcypromine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
This combination stops the body from clearing norepinephrine, which can cause blood pressure to rise to levels that may cause a stroke or heart attack.
What To Do
Avoid using these drugs at the same time. If they must be used in a hospital setting, your vital signs must be monitored constantly by medical staff.
FDA Label Information
Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone,...
Norepinephrine Also Interacts With
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
- Edoxaban moderate
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Phenylephrine major
Frequently Asked Questions
Can I take Norepinephrine and Tranylcypromine together?
This is a major interaction. Avoid using these drugs at the same time. If they must be used in a hospital setting, your vital signs must be monitored constantly by medical staff.
How serious is the interaction between Norepinephrine and Tranylcypromine?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Norepinephrine and Tranylcypromine interact?
This combination stops the body from clearing norepinephrine, which can cause blood pressure to rise to levels that may cause a stroke or heart attack.
Understanding the Norepinephrine and Tranylcypromine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Norepinephrine belongs to the Vasopressor (Alpha-1 Agonist) class and Tranylcypromine belongs to the Monoamine Oxidase Inhibitor (MAOI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: This combination stops the body from clearing norepinephrine, which can cause blood pressure to rise to levels that may cause a stroke or heart attack. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Norepinephrine has 50 total documented interactions on file in this dataset, and Tranylcypromine has 42. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid using these drugs at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Norepinephrine or Tranylcypromine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.