Zolpidem and Darunavir Interaction
Drug interaction information between Zolpidem and Darunavir.
Zolpidem and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Zolpidem and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir slows the removal of zolpidem from your body, which can make the sleep medicine much stronger or last longer than intended.
FDA Label Information
buspirone, diazepam, estazolam, zolpidem ↑ sedatives/hypnotics Titration is recommended when co-administering darunavir/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.
Zolpidem Also Interacts With
- Ketoconazole moderate
- Rifampin moderate
- Imipramine moderate
- Chlorpromazine moderate
- Sertraline minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Zolpidem + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Zolpidem's 9. In the minor band specifically: Zolpidem has 5 (also Sertraline, Fluoxetine, Haloperidol, Nirmatrelvir/Ritonavir); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Zolpidem and Darunavir?
Darunavir slows the removal of zolpidem from your body, which can make the sleep medicine much stronger or last longer than intended.
Darunavir carries more major-labeled pairs than Zolpidem
SPL source-record counts only. This page's band is minor · classes on file: Zolpidem (Non-Benzodiazepine Hypnotic (Z-Drug)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Zolpidem's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Zolpidem
- Sertraline
- Fluoxetine
- Haloperidol
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.