What the FDA labels say about taking them together
Imipramine and zolpidem
Zolpidem's FDA label of August 15, 2022 names imipramine in its drug interactions section; the imipramine label PlainMeds reads does not name zolpidem. The zolpidem label: “Imipramine: decreased alertness observed”
Check it at the source: the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC); the zolpidem FDA label on DailyMed (effective August 15, 2022, Viatris Specialty LLC).
What does the imipramine label say about zolpidem?
Imipramine's label (effective August 11, 2026) does not name zolpidem in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
What does the zolpidem label say about imipramine?
Zolpidem label, drug interactionsImipramine: decreased alertness observed
Ambien label (Cosette Pharmaceuticals, Inc., February 7, 2025), drug interactionsConcomitant use may increase risk of respiratory depression ( 5.7 , 7.1 ) Imipramine: Decreased alertness observed ( 7.1 ) Chlorpromazine:
Zolpidem Tartrate label (Almatica Pharma LLC, October 9, 2025), drug interactionsClinical Impact; Concomitant use of imipramine or chlorpromazine with zolpidem tartrate may lead to an additive effect of decreased alertness and psychomotor performance [see Clinical Pharmacology ()].
Source: FDA drug label (Ambien, NDA019908), Cosette Pharmaceuticals, Inc., effective February 7, 2025 (SPL set 747949c5-2c91-4909-8a07-71b6826f8e97), via openFDA
Source: FDA drug label (Zolpidem Tartrate, NDA215721), Almatica Pharma LLC, effective October 9, 2025 (SPL set 2f1a3600-9bd6-3651-3ab5-1e4e0b0a3916), via openFDA
Source: FDA drug label (Edluar), Viatris Specialty LLC, effective August 15, 2022 (SPL set a32884d0-85b5-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Imipramine | Zolpidem | |
|---|---|---|
| Labeled for | Depression | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0698 per tablet 10 mg tablet | $0.0344 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once