Darunavir and Rosuvastatin Interaction
Drug interaction information between Darunavir and Rosuvastatin.
Darunavir and Rosuvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darunavir and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir increases the levels of rosuvastatin in your blood, which can raise the risk of muscle damage.
FDA Label Information
atorvastatin, pravastatin, rosuvastatin ↑ HMG-CoA reductase inhibitors Co-administration of darunavir/ritonavir with HMG-CoA reductase inhibitors may lead to adverse events such as myopathy. Titrate atorvastatin, pravastatin or rosuvastatin dose carefully and use the lowest necessary dose while monitoring for adverse events.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Rosuvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Rosuvastatin's 21. In the minor band specifically: Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Trazodone); Rosuvastatin has 10 (also Fenofibrate, Warfarin, Brexpiprazole, Estradiol).
What mechanism field is on file for Darunavir and Rosuvastatin?
Darunavir increases the levels of rosuvastatin in your blood, which can raise the risk of muscle damage.
Darunavir carries more major-labeled pairs than Rosuvastatin
SPL source-record counts only. This page's band is minor · classes on file: Darunavir (HIV Protease Inhibitor); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Darunavir has 15 major-labeled pairs vs Rosuvastatin's 3. This page itself is in the minor band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Trazodone
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Fenofibrate
- Warfarin
- Brexpiprazole
- Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.