What the FDA labels say about taking them together
Ketoconazole and zolpidem
Zolpidem's FDA label of August 15, 2022 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name zolpidem. The zolpidem label: “Ketoconazole: combination use may increase effect”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the zolpidem FDA label on DailyMed (effective August 15, 2022, Viatris Specialty LLC).
What does the ketoconazole label say about zolpidem?
Ketoconazole's label (effective January 28, 2026) does not name zolpidem in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the zolpidem label say about ketoconazole?
Zolpidem label, drug interactionsKetoconazole: combination use may increase effect
Ambien label (Cosette Pharmaceuticals, Inc., February 7, 2025), drug interactionsCombination use may decrease effect ( 7.2 ) Ketoconazole: Combination use may increase effect
Source: FDA drug label (Ambien, NDA019908), Cosette Pharmaceuticals, Inc., effective February 7, 2025 (SPL set 747949c5-2c91-4909-8a07-71b6826f8e97), via openFDA
Source: FDA drug label (Edluar), Viatris Specialty LLC, effective August 15, 2022 (SPL set a32884d0-85b5-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Zolpidem | |
|---|---|---|
| Labeled for | Fungal infections | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $0.0344 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once