Zolpidem and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Zolpidem and Nirmatrelvir/Ritonavir.
Zolpidem and Nirmatrelvir/Ritonavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Zolpidem and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paxlovid blocks the way your body breaks down zolpidem, which can make the sleep medicine much stronger than usual.
FDA Label Information
Sedative/hypnotics buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem ↑ sedative/hypnotic A dose decrease may be needed for these drugs when co-administered with PAXLOVID and monitoring for adverse events.
Zolpidem Also Interacts With
- Ketoconazole moderate
- Rifampin moderate
- Imipramine moderate
- Chlorpromazine moderate
- Sertraline minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Zolpidem + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Zolpidem's 9. In the minor band specifically: Zolpidem has 5 (also Sertraline, Fluoxetine, Haloperidol, Darunavir); Nirmatrelvir/Ritonavir has 33 (also Atorvastatin, Bupropion, Trazodone, Prednisone).
What mechanism field is on file for Zolpidem and Nirmatrelvir/Ritonavir?
Paxlovid blocks the way your body breaks down zolpidem, which can make the sleep medicine much stronger than usual.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Zolpidem
SPL source-record counts only. This page's band is minor · classes on file: Zolpidem (Non-Benzodiazepine Hypnotic (Z-Drug)); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Zolpidem's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Zolpidem
- Sertraline
- Fluoxetine
- Haloperidol
- Darunavir
23 major · 30 moderate · 33 minor · 86 total
- Other minor peers for Nirmatrelvir/Ritonavir
- Atorvastatin
- Bupropion
- Trazodone
- Prednisone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.