What the FDA labels say about taking them together
Sertraline and zolpidem
Zolpidem's FDA label of August 15, 2022 names sertraline in its drug interactions section; the sertraline labels PlainMeds reads (3) do not name zolpidem. The zolpidem label: “Sertraline Concomitant administration of zolpidem and sertraline increases exposure to zolpidem.”
Check it at the source: the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC); the zolpidem FDA label on DailyMed (effective August 15, 2022, Viatris Specialty LLC).
What does the sertraline label say about zolpidem?
Sertraline's label (effective August 8, 2023) and its 2 other brand-application labels do not name zolpidem in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
What does the zolpidem label say about sertraline?
Zolpidem label, drug interactionsSertraline Concomitant administration of zolpidem and sertraline increases exposure to zolpidem and may increase the pharmacodynamics effect of zolpidem [see Clinical Pharmacology (12.3) ].
Zolpidem Tartrate label (Almatica Pharma LLC, October 9, 2025), drug interactionsClinical Impact; Concomitant administration of zolpidem and sertraline increases exposure to zolpidem [see Clinical Pharmacology ()].
Source: FDA drug label (Ambien, NDA019908), Cosette Pharmaceuticals, Inc., effective February 7, 2025 (SPL set 747949c5-2c91-4909-8a07-71b6826f8e97), via openFDA
Source: FDA drug label (Zolpidem Tartrate, NDA215721), Almatica Pharma LLC, effective October 9, 2025 (SPL set 2f1a3600-9bd6-3651-3ab5-1e4e0b0a3916), via openFDA
Source: FDA drug label (Edluar), Viatris Specialty LLC, effective August 15, 2022 (SPL set a32884d0-85b5-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sertraline | Zolpidem | |
|---|---|---|
| Labeled for | Depression, Anxiety | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0507 per tablet 100 mg tablet | $0.0344 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once