Zolpidem and Sertraline Interaction
Drug interaction information between Zolpidem and Sertraline.
Zolpidem and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Zolpidem and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sertraline increases the amount of zolpidem that stays in your bloodstream.
FDA Label Information
Sertraline Concomitant administration of Zolpidem and sertraline increases exposure to Zolpidem [see Clinical Pharmacology ( 12.3 )].
Zolpidem Also Interacts With
- Ketoconazole moderate
- Rifampin moderate
- Imipramine moderate
- Chlorpromazine moderate
- Fluoxetine minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Zolpidem + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Zolpidem's 9. In the minor band specifically: Zolpidem has 5 (also Fluoxetine, Haloperidol, Darunavir, Nirmatrelvir/Ritonavir); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Zolpidem and Sertraline?
Sertraline increases the amount of zolpidem that stays in your bloodstream.
Sertraline carries more major-labeled pairs than Zolpidem
SPL source-record counts only. This page's band is minor · classes on file: Zolpidem (Non-Benzodiazepine Hypnotic (Z-Drug)); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Sertraline has 1 major-labeled pair vs Zolpidem's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Zolpidem
- Fluoxetine
- Haloperidol
- Darunavir
- Nirmatrelvir/Ritonavir
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.