What the FDA labels say about taking them together
Fluoxetine and zolpidem
Zolpidem's FDA label of August 15, 2022 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name zolpidem. The zolpidem label: “Fluoxetine After multiple doses of zolpidem tartrate and fluoxetine an increase in the zolpidem half-life (17%) was observed.”
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the zolpidem FDA label on DailyMed (effective August 15, 2022, Viatris Specialty LLC).
What does the fluoxetine label say about zolpidem?
Fluoxetine's label (effective January 8, 2026) does not name zolpidem in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the zolpidem label say about fluoxetine?
Zolpidem label, drug interactionsFluoxetine After multiple doses of zolpidem tartrate and fluoxetine an increase in the zolpidem half-life (17%) was observed.
Source: FDA drug label (Edluar), Viatris Specialty LLC, effective August 15, 2022 (SPL set a32884d0-85b5-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Zolpidem | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $0.0344 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once