Zolpidem and Fluoxetine Interaction
Drug interaction information between Zolpidem and Fluoxetine.
Zolpidem and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Zolpidem and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine causes zolpidem to stay in your body for a longer period of time.
FDA Label Information
Fluoxetine After multiple doses of Zolpidem Tartrate and fluoxetine an increase in the Zolpidem half-life (17%) was observed.
Zolpidem Also Interacts With
- Ketoconazole moderate
- Rifampin moderate
- Imipramine moderate
- Chlorpromazine moderate
- Sertraline minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Zolpidem + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Zolpidem's 9. In the minor band specifically: Zolpidem has 5 (also Sertraline, Haloperidol, Darunavir, Nirmatrelvir/Ritonavir); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Zolpidem and Fluoxetine?
Fluoxetine causes zolpidem to stay in your body for a longer period of time.
Fluoxetine carries more major-labeled pairs than Zolpidem
SPL source-record counts only. This page's band is minor · classes on file: Zolpidem (Non-Benzodiazepine Hypnotic (Z-Drug)); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Zolpidem's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Zolpidem
- Sertraline
- Haloperidol
- Darunavir
- Nirmatrelvir/Ritonavir
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.