Zolpidem and Fluoxetine Interaction
Drug interaction information between Zolpidem and Fluoxetine.
Zolpidem and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Zolpidem and Fluoxetine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluoxetine causes zolpidem to stay in your body for a longer period of time.
What To Do
Be aware of increased drowsiness and consult your healthcare provider about your zolpidem dose.
FDA Label Information
Fluoxetine After multiple doses of Zolpidem Tartrate and fluoxetine an increase in the Zolpidem half-life (17%) was observed.
Zolpidem Also Interacts With
- Ketoconazole moderate
- Rifampin moderate
- Imipramine moderate
- Chlorpromazine moderate
- Sertraline minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
Can I take Zolpidem and Fluoxetine together?
This is a minor interaction. Be aware of increased drowsiness and consult your healthcare provider about your zolpidem dose.
How serious is the interaction between Zolpidem and Fluoxetine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Zolpidem and Fluoxetine interact?
Fluoxetine causes zolpidem to stay in your body for a longer period of time.
Understanding the Zolpidem and Fluoxetine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Zolpidem belongs to the Non-Benzodiazepine Hypnotic (Z-Drug) class and Fluoxetine belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluoxetine causes zolpidem to stay in your body for a longer period of time. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Zolpidem has 9 total documented interactions on file in this dataset, and Fluoxetine has 68. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Be aware of increased drowsiness and consult your healthcare provider about your zolpidem dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Zolpidem or Fluoxetine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.