What the FDA labels say about taking them together
Darunavir and metoprolol
Darunavir's FDA label of August 29, 2025 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Clinical monitoring of patients is recommended. A dose decrease may be needed for these drugs when co-administered with PREZISTA/ritonavir and a lower dose of the beta blocker should be considered.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC).
What does the darunavir label say about metoprolol?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: β-Blockers: e.g. carvedilol, metoprolol, timolol; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ beta-blockers; Clinical Comment: Clinical monitoring of patients is recommended. A dose decrease may be needed for these drugs when co-administered with PREZISTA/ritonavir and a lower dose of the beta blocker should be considered.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the metoprolol label say about darunavir?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Metoprolol | |
|---|---|---|
| Labeled for | HIV | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.085 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once