Darunavir and Metoprolol Interaction
Drug interaction information between Darunavir and Metoprolol.
Darunavir and Metoprolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darunavir and Metoprolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir can slow down how the body breaks down metoprolol, which causes the level of the heart medicine to rise in the blood.
FDA Label Information
carvedilol, metoprolol, timolol ↑ beta-blockers Clinical monitoring of patients is recommended.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Metoprolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Metoprolol's 18. In the minor band specifically: Darunavir has 70 (also Amlodipine, Sertraline, Rosuvastatin, Trazodone); Metoprolol has 14 (also Fluoxetine, Paroxetine, Propafenone, Epinephrine).
What mechanism field is on file for Darunavir and Metoprolol?
Darunavir can slow down how the body breaks down metoprolol, which causes the level of the heart medicine to rise in the blood.
Darunavir carries more major-labeled pairs than Metoprolol
SPL source-record counts only. This page's band is minor · classes on file: Darunavir (HIV Protease Inhibitor); Metoprolol (Beta-Blocker).
Darunavir has 15 major-labeled pairs vs Metoprolol's 1. This page itself is in the minor band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Sertraline
- Rosuvastatin
- Trazodone
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Propafenone
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.