Zolpidem and Rifampin Interaction
Drug interaction information between Zolpidem and Rifampin.
Zolpidem and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Zolpidem and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up how fast your body gets rid of zolpidem, which makes the sleep medicine much less effective.
FDA Label Information
7 DRUG INTERACTIONS CNS depressants, including alcohol: Possible adverse additive CNS- depressant effects ( 5.1 , 7.1 ) Opioids: Concomitant use may increase risk of respiratory depression ( 5.7 , 7.1 ) Imipramine: Decreased alertness observed ( 7.1 ) Chlorpromazine: Impaired alertness and psychomotor performance observed ( 7.1 ) CYP3A4 inducers (rifampin or St. CYP3A4 Inducers Rifampin Rifampin, a CYP3A4 inducer, significantly reduced the exposure to and the pharmacodynamic effects of Zolpidem. Use of Rifampin in combination with Zolpidem may decrease the efficacy of Zolpidem and is not...
Zolpidem Also Interacts With
- Ketoconazole moderate
- Imipramine moderate
- Chlorpromazine moderate
- Sertraline minor
- Fluoxetine minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Zolpidem + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Zolpidem's 9. In the moderate band specifically: Zolpidem has 4 (also Ketoconazole, Imipramine, Chlorpromazine); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Zolpidem and Rifampin?
Rifampin speeds up how fast your body gets rid of zolpidem, which makes the sleep medicine much less effective.
Rifampin carries more major-labeled pairs than Zolpidem
SPL source-record counts only. This page's band is moderate · classes on file: Zolpidem (Non-Benzodiazepine Hypnotic (Z-Drug)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Zolpidem's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 5 minor · 9 total
- Other moderate peers for Zolpidem
- Ketoconazole
- Imipramine
- Chlorpromazine
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.