Zolpidem and Chlorpromazine Interaction
Drug interaction information between Zolpidem and Chlorpromazine.
Zolpidem and Chlorpromazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Zolpidem and Chlorpromazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines both cause drowsiness and slow down your physical reactions, which can impair your coordination and alertness.
FDA Label Information
7 DRUG INTERACTIONS CNS depressants, including alcohol: Possible adverse additive CNS- depressant effects ( 5.1 , 7.1 ) Opioids: Concomitant use may increase risk of respiratory depression ( 5.7 , 7.1 ) Imipramine: Decreased alertness observed ( 7.1 ) Chlorpromazine: Impaired alertness and psychomotor performance observed ( 7.1 ) CYP3A4 inducers (rifampin or St. Limit dosage and duration of concomitant use of Zolpidem Tartrate Tablets and opioids [ see Dosage and Administration ( 2.3 ), Warnings and Precautions ( 5.7 )] Imipramine, Chlorpromazine Imipramine in combination with Zolpidem...
Zolpidem Also Interacts With
- Ketoconazole moderate
- Rifampin moderate
- Imipramine moderate
- Sertraline minor
- Fluoxetine minor
Chlorpromazine Also Interacts With
- Desmopressin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
- Carbamazepine minor
- Clozapine minor
Frequently Asked Questions
What SPL severity band is on file for Zolpidem + Chlorpromazine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Chlorpromazine has 11 labeled pairs on file vs Zolpidem's 9. In the moderate band specifically: Zolpidem has 4 (also Ketoconazole, Rifampin, Imipramine); Chlorpromazine has 4 (also Desmopressin, Tetrabenazine, Tranylcypromine).
What mechanism field is on file for Zolpidem and Chlorpromazine?
These medicines both cause drowsiness and slow down your physical reactions, which can impair your coordination and alertness.
Chlorpromazine's labeled portfolio outnumbers Zolpidem
SPL source-record counts only. This page's band is moderate · classes on file: Zolpidem (Non-Benzodiazepine Hypnotic (Z-Drug)); Chlorpromazine (Typical Antipsychotic (Phenothiazine)).
0 major · 4 moderate · 5 minor · 9 total
- Other moderate peers for Zolpidem
- Ketoconazole
- Rifampin
- Imipramine
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Chlorpromazine
- Desmopressin
- Tetrabenazine
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.