What the FDA labels say about taking them together
Chlorpromazine and zolpidem
Zolpidem's FDA label of August 15, 2022 names chlorpromazine in its drug interactions section; the chlorpromazine label PlainMeds reads does not name zolpidem. The zolpidem label: “Concomitant use may increase risk of respiratory depression Imipramine: Decreased alertness observed Chlorpromazine:”
Check it at the source: the chlorpromazine FDA label on DailyMed (effective May 12, 2026, Amneal Pharmaceuticals NY LLC); the zolpidem FDA label on DailyMed (effective August 15, 2022, Viatris Specialty LLC).
What does the chlorpromazine label say about zolpidem?
Chlorpromazine's label (effective May 12, 2026) does not name zolpidem in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CHLORPROMAZINE HYDROCHLORIDE), Amneal Pharmaceuticals NY LLC, effective May 12, 2026 (SPL set aa086a21-de85-4b03-af58-49b70acf8cf0), via openFDA; the full label on DailyMed
What does the zolpidem label say about chlorpromazine?
Zolpidem label, drug interactionsImipramine, Chlorpromazine Imipramine in combination with zolpidem produced no pharmacokinetic interaction other than a 20% decrease in peak levels of imipramine, but there was an additive effect of decreased alertness.
Ambien label (Cosette Pharmaceuticals, Inc., February 7, 2025), drug interactionsConcomitant use may increase risk of respiratory depression ( 5.7 , 7.1 ) Imipramine: Decreased alertness observed ( 7.1 ) Chlorpromazine:
Zolpidem Tartrate label (Almatica Pharma LLC, October 9, 2025), drug interactionsClinical Impact; Concomitant use of imipramine or chlorpromazine with zolpidem tartrate may lead to an additive effect of decreased alertness and psychomotor performance [see Clinical Pharmacology ()].
Source: FDA drug label (Ambien, NDA019908), Cosette Pharmaceuticals, Inc., effective February 7, 2025 (SPL set 747949c5-2c91-4909-8a07-71b6826f8e97), via openFDA
Source: FDA drug label (Zolpidem Tartrate, NDA215721), Almatica Pharma LLC, effective October 9, 2025 (SPL set 2f1a3600-9bd6-3651-3ab5-1e4e0b0a3916), via openFDA
Source: FDA drug label (Edluar), Viatris Specialty LLC, effective August 15, 2022 (SPL set a32884d0-85b5-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlorpromazine | Zolpidem | |
|---|---|---|
| Labeled for | Schizophrenia, Nausea and vomiting | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.552 per tablet 100 mg tablet | $0.0344 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once