What the FDA labels say about taking them together
Darunavir and sertraline
Darunavir's FDA label of August 29, 2025 names sertraline in its drug interactions section; the sertraline labels PlainMeds reads (3) do not name darunavir. The darunavir label: “If either sertraline or paroxetine is initiated in patients receiving PREZISTA/ritonavir, dose titrating the SSRI based on a clinical assessment of antidepressant response is recommended. …”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the darunavir label say about sertraline?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: paroxetine, sertraline; Effect on Concentration of Darunavir Or Concomitant Drug: ↓ paroxetine ↓ sertraline; Clinical Comment: If either sertraline or paroxetine is initiated in patients receiving PREZISTA/ritonavir, dose titrating the SSRI based on a clinical assessment of antidepressant response is recommended. Monitor for antidepressant response in patients on a stable dose of sertraline or paroxetine who start treatment with PREZISTA/ritonavir.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the sertraline label say about darunavir?
Sertraline's label (effective August 8, 2023) and its 2 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Sertraline | |
|---|---|---|
| Labeled for | HIV | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once