Darunavir and Amlodipine Interaction
Drug interaction information between Darunavir and Amlodipine.
Darunavir and Amlodipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darunavir and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir can increase the amount of amlodipine in your blood, which may make its effects or side effects stronger.
FDA Label Information
Calcium Channel Blockers : amlodipine, diltiazem, felodipine, nicardipine, nifedipine, verapamil ↑ calcium channel blockers Clinical monitoring of patients is recommended.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Amlodipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Amlodipine's 15. In the minor band specifically: Darunavir has 70 (also Metoprolol, Sertraline, Rosuvastatin, Trazodone); Amlodipine has 10 (also Sildenafil, Cyclosporine, Amlodipine/Valsartan, Clarithromycin).
What mechanism field is on file for Darunavir and Amlodipine?
Darunavir can increase the amount of amlodipine in your blood, which may make its effects or side effects stronger.
Darunavir carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is minor · classes on file: Darunavir (HIV Protease Inhibitor); Amlodipine (Calcium Channel Blocker).
Darunavir has 15 major-labeled pairs vs Amlodipine's 4. This page itself is in the minor band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Metoprolol
- Sertraline
- Rosuvastatin
- Trazodone
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Sildenafil
- Cyclosporine
- Amlodipine/Valsartan
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.