Trazodone and Clopidogrel Interaction
Drug interaction information between Trazodone and Clopidogrel.
Trazodone and Clopidogrel have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trazodone and Clopidogrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can both make it harder for your blood to clot. This increases the chance of bleeding or bruising.
FDA Label Information
Examples: warfarin, rivaroxaban, dabigatran, clopidogrel Strong CYP3A4 Inhibitors Clinical Impact: The concomitant use of trazodone and strong CYP3A4 inhibitors increased the exposure of trazodone compared to the use of trazodone alone .
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Frequently Asked Questions
What SPL severity band is on file for Trazodone + Clopidogrel?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trazodone has 40 labeled pairs on file vs Clopidogrel's 19. In the minor band specifically: Trazodone has 35 (also Tramadol, Buspirone, Rivaroxaban, Warfarin); Clopidogrel has 10 (also Morphine, Repaglinide, Lansoprazole, Dexlansoprazole).
What mechanism field is on file for Trazodone and Clopidogrel?
These drugs can both make it harder for your blood to clot. This increases the chance of bleeding or bruising.
Trazodone carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is minor · classes on file: Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)); Clopidogrel (Antiplatelet Agent).
Trazodone has 1 major-labeled pair vs Clopidogrel's 0. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 35 minor · 40 total
- Other minor peers for Trazodone
- Tramadol
- Buspirone
- Rivaroxaban
- Warfarin
0 major · 9 moderate · 10 minor · 19 total
- Other minor peers for Clopidogrel
- Morphine
- Repaglinide
- Lansoprazole
- Dexlansoprazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.