Trazodone and Warfarin Interaction
Drug interaction information between Trazodone and Warfarin.
Trazodone and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trazodone and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Trazodone can interfere with how warfarin works, which may cause your blood to clot too slowly or too quickly.
FDA Label Information
Warfarin: Monitor for increased or decreased prothrombin time ( 7 ). Warfarin There have been reports of altered (either increased or decreased) prothrombin times in taking both warfarin and trazodone. For patients taking warfarin, carefully monitor the international normalized ratio (INR) when initiating or discontinuing trazodone [see Warnings and Precautions (5.5)].
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Trazodone + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Trazodone's 40. In the minor band specifically: Trazodone has 35 (also Tramadol, Buspirone, Clopidogrel, Rivaroxaban); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Trazodone and Warfarin?
Trazodone can interfere with how warfarin works, which may cause your blood to clot too slowly or too quickly.
Warfarin carries more major-labeled pairs than Trazodone
SPL source-record counts only. This page's band is minor · classes on file: Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Trazodone's 1. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 35 minor · 40 total
- Other minor peers for Trazodone
- Tramadol
- Buspirone
- Clopidogrel
- Rivaroxaban
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.