Trazodone and Buspirone Interaction
Drug interaction information between Trazodone and Buspirone.
Trazodone and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trazodone and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines both increase serotonin in your body. Combining them can lead to a dangerous buildup of this chemical.
FDA Label Information
Examples: triptans, antidepressants (tricyclic and serotonin uptake inhibitors), fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Trazodone + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trazodone has 40 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Trazodone has 35 (also Tramadol, Clopidogrel, Rivaroxaban, Warfarin); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Trazodone and Buspirone?
These medicines both increase serotonin in your body. Combining them can lead to a dangerous buildup of this chemical.
Trazodone carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)); Buspirone (Azapirone Anxiolytic).
Trazodone has 1 major-labeled pair vs Buspirone's 0. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 35 minor · 40 total
- Other minor peers for Trazodone
- Tramadol
- Clopidogrel
- Rivaroxaban
- Warfarin
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.