Trazodone and Rivaroxaban Interaction
Drug interaction information between Trazodone and Rivaroxaban.
Trazodone and Rivaroxaban have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trazodone and Rivaroxaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can slow down how your body processes trazodone, leading to higher levels of the medicine in your blood.
FDA Label Information
Examples: warfarin, rivaroxaban, dabigatran, clopidogrel Strong CYP3A4 Inhibitors Clinical Impact: The concomitant use of trazodone and strong CYP3A4 inhibitors increased the exposure of trazodone compared to the use of trazodone alone .
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Rivaroxaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Ketoconazole moderate
- Carbamazepine moderate
Frequently Asked Questions
What SPL severity band is on file for Trazodone + Rivaroxaban?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trazodone has 40 labeled pairs on file vs Rivaroxaban's 14. In the minor band specifically: Trazodone has 35 (also Tramadol, Buspirone, Clopidogrel, Warfarin); Rivaroxaban has 1.
What mechanism field is on file for Trazodone and Rivaroxaban?
Taking these drugs together can slow down how your body processes trazodone, leading to higher levels of the medicine in your blood.
Trazodone carries more major-labeled pairs than Rivaroxaban
SPL source-record counts only. This page's band is minor · classes on file: Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)); Rivaroxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
Trazodone has 1 major-labeled pair vs Rivaroxaban's 0. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 35 minor · 40 total
- Other minor peers for Trazodone
- Tramadol
- Buspirone
- Clopidogrel
- Warfarin
0 major · 13 moderate · 1 minor · 14 total
Rivaroxaban has no other minor-band peer in this dataset besides Trazodone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.