Trazodone and Linezolid Interaction
Drug interaction information between Trazodone and Linezolid.
Trazodone and Linezolid have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Trazodone and Linezolid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid acts like a special type of medicine that can cause a dangerous buildup of a brain chemical called serotonin when mixed with trazodone. This can lead to a serious condition called serotonin syndrome.
FDA Label Information
Intervention: Trazodone is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Contraindications (4), Dosage and Administration (2.3, 2.4), and Warnings and Precautions (5.2)].
Trazodone Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Tramadol minor
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Frequently Asked Questions
What SPL severity band is on file for Trazodone + Linezolid?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trazodone has 40 labeled pairs on file vs Linezolid's 29. In the major band specifically: Trazodone has 1; Linezolid has 8 (also Citalopram, Escitalopram, Mirtazapine, Paroxetine).
What mechanism field is on file for Trazodone and Linezolid?
Linezolid acts like a special type of medicine that can cause a dangerous buildup of a brain chemical called serotonin when mixed with trazodone. This can lead to a serious condition called serotonin syndrome.
Linezolid carries more major-labeled pairs than Trazodone
SPL source-record counts only. This page's band is major · classes on file: Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)); Linezolid (Oxazolidinone Antibiotic).
Linezolid has 8 major-labeled pairs vs Trazodone's 1.
1 major · 4 moderate · 35 minor · 40 total
Trazodone has no other major-band peer in this dataset besides Linezolid.
8 major · 3 moderate · 18 minor · 29 total
- Other major peers for Linezolid
- Citalopram
- Escitalopram
- Mirtazapine
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.