Clopidogrel and Repaglinide Interaction
Drug interaction information between Clopidogrel and Repaglinide.
Clopidogrel and Repaglinide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clopidogrel and Repaglinide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clopidogrel blocks the enzyme that breaks down repaglinide. This causes repaglinide levels to rise much higher than normal in your blood.
FDA Label Information
( 7.7 ) Repaglinide (CYP2C8 substrates): Increases substrate plasma concentrations. 7.8 Repaglinide (CYP2C8 Substrates) The acyl-β-glucuronide metabolite of clopidogrel is a strong inhibitor of CYP2C8. Clopidogrel increased repaglinide exposures by 3.9-fold to 5.1-fold [see Clinical Pharmacology (12.3) ] .
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Clonidine moderate
- Cyclosporine moderate
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Clopidogrel + Repaglinide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Repaglinide has 22 labeled pairs on file vs Clopidogrel's 19. In the minor band specifically: Clopidogrel has 10 (also Morphine, Lansoprazole, Dexlansoprazole, Bupropion); Repaglinide has 17 (also Albuterol, Fluoxetine, Montelukast, Ketoconazole).
What mechanism field is on file for Clopidogrel and Repaglinide?
Clopidogrel blocks the enzyme that breaks down repaglinide. This causes repaglinide levels to rise much higher than normal in your blood.
Repaglinide carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is minor · classes on file: Clopidogrel (Antiplatelet Agent); Repaglinide (Meglitinide).
Repaglinide has 2 major-labeled pairs vs Clopidogrel's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 10 minor · 19 total
- Other minor peers for Clopidogrel
- Morphine
- Lansoprazole
- Dexlansoprazole
- Bupropion
2 major · 3 moderate · 17 minor · 22 total
- Other minor peers for Repaglinide
- Albuterol
- Fluoxetine
- Montelukast
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.