Trazodone and Phenelzine Interaction
Drug interaction information between Trazodone and Phenelzine.
Trazodone and Phenelzine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Trazodone and Phenelzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications increase the amount of serotonin in your brain, which can lead to a dangerous reaction called serotonin syndrome.
FDA Label Information
Examples: isocarboxazid, moclobemide, phenelzine, selegiline, tranylcypromine Other Serotonergic Drugs Clinical Impact: The concomitant use of serotonergic drugs including trazodone and other serotonergic drugs increases the risk of serotonin syndrome.
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Tranylcypromine moderate
- Selegiline moderate
- Tramadol minor
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Frequently Asked Questions
What SPL severity band is on file for Trazodone + Phenelzine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trazodone has 40 labeled pairs on file vs Phenelzine's 27. In the moderate band specifically: Trazodone has 4 (also Aspirin, Tranylcypromine, Selegiline); Phenelzine has 11 (also Sertraline, Fluoxetine, Citalopram, Venlafaxine).
What mechanism field is on file for Trazodone and Phenelzine?
Both of these medications increase the amount of serotonin in your brain, which can lead to a dangerous reaction called serotonin syndrome.
Trazodone carries more major-labeled pairs than Phenelzine
SPL source-record counts only. This page's band is moderate · classes on file: Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)); Phenelzine (Monoamine Oxidase Inhibitor (MAOI)).
Trazodone has 1 major-labeled pair vs Phenelzine's 0. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 35 minor · 40 total
- Other moderate peers for Trazodone
- Aspirin
- Tranylcypromine
- Selegiline
0 major · 11 moderate · 16 minor · 27 total
- Other moderate peers for Phenelzine
- Sertraline
- Fluoxetine
- Citalopram
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.