Clopidogrel and Rifampin Interaction
Drug interaction information between Clopidogrel and Rifampin.
Clopidogrel and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clopidogrel and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the process that turns clopidogrel into its active form in the body. This leads to higher levels of the active drug, which can make your blood too thin and increase the risk of bleeding.
FDA Label Information
Rifampin strongly induces CYP2C19 resulting to both an increase level of clopidogrel active metabolite and platelet inhibition, which in particular might potentiate the risk of bleeding.
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Norepinephrine moderate
- Apixaban moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Clopidogrel + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Clopidogrel's 19. In the moderate band specifically: Clopidogrel has 9 (also Omeprazole, Warfarin, Esomeprazole, Norepinephrine); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Clopidogrel and Rifampin?
Rifampin speeds up the process that turns clopidogrel into its active form in the body. This leads to higher levels of the active drug, which can make your blood too thin and increase the risk of bleeding.
Rifampin carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is moderate · classes on file: Clopidogrel (Antiplatelet Agent); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Clopidogrel's 0. This page itself is in the moderate band, not the major band.
0 major · 9 moderate · 10 minor · 19 total
- Other moderate peers for Clopidogrel
- Omeprazole
- Warfarin
- Esomeprazole
- Norepinephrine
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.