Clopidogrel and Lansoprazole Interaction
Drug interaction information between Clopidogrel and Lansoprazole.
Clopidogrel and Lansoprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clopidogrel and Lansoprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lansoprazole has a small effect on how well clopidogrel prevents blood clots. It is less likely to cause problems than other similar heartburn drugs like omeprazole.
FDA Label Information
Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Lansoprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Rifampin moderate
- Tacrolimus Topical moderate
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Clopidogrel + Lansoprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clopidogrel has 19 labeled pairs on file vs Lansoprazole's 14. In the minor band specifically: Clopidogrel has 10 (also Morphine, Repaglinide, Dexlansoprazole, Bupropion); Lansoprazole has 10 (also Warfarin, Methotrexate, Ketoconazole, Itraconazole).
What mechanism field is on file for Clopidogrel and Lansoprazole?
Lansoprazole has a small effect on how well clopidogrel prevents blood clots. It is less likely to cause problems than other similar heartburn drugs like omeprazole.
Lansoprazole carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is minor · classes on file: Clopidogrel (Antiplatelet Agent); Lansoprazole (Proton Pump Inhibitor (PPI)).
Lansoprazole has 2 major-labeled pairs vs Clopidogrel's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 10 minor · 19 total
- Other minor peers for Clopidogrel
- Morphine
- Repaglinide
- Dexlansoprazole
- Bupropion
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Lansoprazole
- Warfarin
- Methotrexate
- Ketoconazole
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.