Clopidogrel and Dexlansoprazole Interaction
Drug interaction information between Clopidogrel and Dexlansoprazole.
Clopidogrel and Dexlansoprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clopidogrel and Dexlansoprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dexlansoprazole may slightly reduce clopidogrel's effectiveness, but it does so less than other common stomach acid medicines.
FDA Label Information
Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Dexlansoprazole Also Interacts With
- Rifampin moderate
- Warfarin minor
- Methotrexate minor
- Ketoconazole minor
- Itraconazole minor
Frequently Asked Questions
What SPL severity band is on file for Clopidogrel + Dexlansoprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clopidogrel has 19 labeled pairs on file vs Dexlansoprazole's 8. In the minor band specifically: Clopidogrel has 10 (also Morphine, Repaglinide, Lansoprazole, Bupropion); Dexlansoprazole has 7 (also Warfarin, Methotrexate, Ketoconazole, Itraconazole).
What mechanism field is on file for Clopidogrel and Dexlansoprazole?
Dexlansoprazole may slightly reduce clopidogrel's effectiveness, but it does so less than other common stomach acid medicines.
Clopidogrel's labeled portfolio outnumbers Dexlansoprazole
SPL source-record counts only. This page's band is minor · classes on file: Clopidogrel (Antiplatelet Agent); Dexlansoprazole (Proton Pump Inhibitor (PPI)).
0 major · 9 moderate · 10 minor · 19 total
- Other minor peers for Clopidogrel
- Morphine
- Repaglinide
- Lansoprazole
- Bupropion
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Dexlansoprazole
- Warfarin
- Methotrexate
- Ketoconazole
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.