What the FDA labels say about taking them together
Clopidogrel and omeprazole
Clopidogrel's FDA label of May 30, 2025 names omeprazole in its drug interactions section, and omeprazole's label names clopidogrel too. The omeprazole label: “Concomitant use of omeprazole 80 mg results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition. …”
Check it at the source: the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the clopidogrel label say about omeprazole?
Clopidogrel label, drug interactionsOmeprazole or Esomeprazole Avoid concomitant use of Plavix with omeprazole or esomeprazole.
Clopidogrel label, warnings and precautionsWARNINGS AND PRECAUTIONS CYP2C19 inhibitors: Avoid concomitant use of omeprazole or esomeprazole.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
What does the omeprazole label say about clopidogrel?
Omeprazole label, drug interactionsClopidogrel Clinical Impact: Concomitant use of omeprazole 80 mg results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition. There are no adequate combination studies of a lower dose of omeprazole or a higher dose of clopidogrel in comparison with the approved dose of clopidogrel. Intervention: Avoid concomitant use with omeprazole. Consider use of alternative anti-platelet therapy [see Warnings and Precautions ()].
Omeprazole label, warnings and precautionsInhibition of platelet aggregation by clopidogrel is entirely due to an active metabolite.
Prilosec label (Covis Pharma US, Inc, March 19, 2024), warnings and precautionsInteraction with Clopidogrel: Avoid concomitant use of PRILOSEC.
Source: FDA drug label (Prilosec, NDA022056), Covis Pharma US, Inc, effective March 19, 2024 (SPL set b6761f84-53ac-4745-a8c8-1e5427d7e179), via openFDA
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clopidogrel | Omeprazole | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0472 per tablet 75 mg tablet | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once