Clopidogrel and Esomeprazole Interaction
Drug interaction information between Clopidogrel and Esomeprazole.
Clopidogrel and Esomeprazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clopidogrel and Esomeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Esomeprazole keeps clopidogrel from being activated in your body. This prevents the blood thinner from doing its job of protecting your heart and blood vessels.
FDA Label Information
Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole. A similar reduction in antiplatelet activity was observed with esomeprazole when given concomitantly with clopidogrel. Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Rifampin moderate
- Norepinephrine moderate
- Apixaban moderate
Esomeprazole Also Interacts With
- Posaconazole major
- Digoxin minor
- Risedronate minor
Frequently Asked Questions
What SPL severity band is on file for Clopidogrel + Esomeprazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clopidogrel has 19 labeled pairs on file vs Esomeprazole's 4. In the moderate band specifically: Clopidogrel has 9 (also Omeprazole, Warfarin, Rifampin, Norepinephrine); Esomeprazole has 1.
What mechanism field is on file for Clopidogrel and Esomeprazole?
Esomeprazole keeps clopidogrel from being activated in your body. This prevents the blood thinner from doing its job of protecting your heart and blood vessels.
Esomeprazole carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is moderate · classes on file: Clopidogrel (Antiplatelet Agent); Esomeprazole (Proton Pump Inhibitor (PPI)).
Esomeprazole has 1 major-labeled pair vs Clopidogrel's 0. This page itself is in the moderate band, not the major band.
0 major · 9 moderate · 10 minor · 19 total
- Other moderate peers for Clopidogrel
- Omeprazole
- Warfarin
- Rifampin
- Norepinephrine
1 major · 1 moderate · 2 minor · 4 total
Esomeprazole has no other moderate-band peer in this dataset besides Clopidogrel.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.