What the FDA labels say about taking them together
Clopidogrel and esomeprazole
Clopidogrel's FDA label of May 30, 2025 names esomeprazole in its drug interactions section, and esomeprazole's label names clopidogrel too. The esomeprazole label: “Concomitant use of esomeprazole 40 mg resulted in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition. …”
Check it at the source: the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC); the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC).
What does the clopidogrel label say about esomeprazole?
Clopidogrel label, drug interactionsOmeprazole or Esomeprazole Avoid concomitant use of Plavix with omeprazole or esomeprazole.
Clopidogrel label, warnings and precautionsWARNINGS AND PRECAUTIONS CYP2C19 inhibitors: Avoid concomitant use of omeprazole or esomeprazole.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
What does the esomeprazole label say about clopidogrel?
Esomeprazole label, drug interactions (prescription label)Clopidogrel Clinical Impact: Concomitant use of esomeprazole 40 mg resulted in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition. There are no adequate combination studies of a lower dose of esomeprazole or a higher dose of clopidogrel in comparison with the approved dose of clopidogrel. Intervention: Avoid concomitant use with NEXIUM Consider use of alternative anti-platelet therapy [see ].
Esomeprazole label, warnings and precautions (prescription label)Interaction with Clopidogrel: Avoid concomitant use of NEXIUM.
Esomeprazole Strontium label (R2 Pharma, LLC, September 22, 2016), drug interactionsConcomitant use of esomeprazole 40 mg results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition.
Esomeprazole Strontium label (R2 Pharma, LLC, September 22, 2016), warnings and precautionsAvoid concomitant use of esomeprazole strontium with clopidogrel.
Source: FDA drug label (Esomeprazole Strontium, NDA202342), R2 Pharma, LLC, effective September 22, 2016 (SPL set 3c916d32-f9e9-1d15-e054-00144ff88e88), via openFDA
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clopidogrel | Esomeprazole | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0472 per tablet 75 mg tablet | $0.145 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once