What the FDA labels say about taking them together
Clopidogrel and morphine
Clopidogrel's FDA label of May 30, 2025 names morphine in its drug interactions section, and morphine's label names clopidogrel too. The morphine label: “The co-administration of oral P2Y 12 inhibitors and intravenous morphine sulfate can decrease the absorption and peak concentration of oral P2Y 12 inhibitors and delay the onset of antiplatelet effect.”
Check it at the source: the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC); the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack).
What does the clopidogrel label say about morphine?
Clopidogrel label, drug interactionsConsider the use of a parenteral antiplatelet agent in acute coronary syndrome patients requiring coadministration of morphine or other opioid agonists.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
What does the morphine label say about clopidogrel?
Morphine Sulfate label (Fresenius Kabi, USA LLC, August 31, 2026), drug interactionsOral P2Y 12 Inhibitors Clinical Impact: The co-administration of oral P2Y 12 inhibitors and intravenous morphine sulfate can decrease the absorption and peak concentration of oral P2Y 12 inhibitors and delay the onset of antiplatelet effect. Intervention: Consider the use of a parenteral antiplatelet agent in the setting of acute coronary syndrome requiring co-administration of intravenous morphine sulfate. Examples: clopidogrel, prasugrel, ticagrelor
Source: FDA drug label (Morphine Sulfate, NDA204223), Fresenius Kabi, USA LLC, effective August 31, 2026 (SPL set 1f53de80-efc8-4930-b3e3-fba0d026af05), via openFDA
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clopidogrel | Morphine | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0472 per tablet 75 mg tablet | $0.226 per tablet 15 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once