Clopidogrel and Morphine Interaction
Drug interaction information between Clopidogrel and Morphine.
Clopidogrel and Morphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clopidogrel and Morphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Morphine can delay the body's ability to use clopidogrel, which stops the medicine from preventing blood clots as well as it should.
FDA Label Information
Consider the use of a parenteral antiplatelet agent in acute coronary syndrome patients requiring coadministration of morphine or other opioid agonists.
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Morphine Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Clopidogrel + Morphine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Morphine has 30 labeled pairs on file vs Clopidogrel's 19. In the minor band specifically: Clopidogrel has 10 (also Repaglinide, Lansoprazole, Dexlansoprazole, Bupropion); Morphine has 30 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine).
What mechanism field is on file for Clopidogrel and Morphine?
Morphine can delay the body's ability to use clopidogrel, which stops the medicine from preventing blood clots as well as it should.
Morphine's labeled portfolio outnumbers Clopidogrel
SPL source-record counts only. This page's band is minor · classes on file: Clopidogrel (Antiplatelet Agent); Morphine (Opioid Analgesic).
0 major · 9 moderate · 10 minor · 19 total
- Other minor peers for Clopidogrel
- Repaglinide
- Lansoprazole
- Dexlansoprazole
- Bupropion
0 major · 0 moderate · 30 minor · 30 total
- Other minor peers for Morphine
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.