Clopidogrel and Warfarin Interaction
Drug interaction information between Clopidogrel and Warfarin.
Clopidogrel and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clopidogrel and Warfarin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both medicines work to prevent blood clots, but they do it in different ways. Using them together makes it much easier for you to bleed or bruise.
What To Do
Monitor yourself closely for any unusual bleeding or bruising. Your doctor will need to check your health frequently while you are on both drugs.
FDA Label Information
( 7.3 ) Nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, selective serotonin and serotonin norepinephrine reuptake inhibitors (SSRIs, SNRIs): Increases risk of bleeding. 7.5 Warfarin (CYP2C9 Substrates) Although the administration of clopidogrel 75 mg per day did not modify the pharmacokinetics of S-warfarin (a CYP2C9 substrate) or INR in patients receiving long-term warfarin therapy, coadministration of clopidogrel with warfarin increases the risk of bleeding because of independent effects on hemostasis.
Clopidogrel Also Interacts With
- Omeprazole moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
- Apixaban moderate
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
Can I take Clopidogrel and Warfarin together?
This is a moderate interaction. Monitor yourself closely for any unusual bleeding or bruising. Your doctor will need to check your health frequently while you are on both drugs.
How serious is the interaction between Clopidogrel and Warfarin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Clopidogrel and Warfarin interact?
Both medicines work to prevent blood clots, but they do it in different ways. Using them together makes it much easier for you to bleed or bruise.
Understanding the Clopidogrel and Warfarin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Clopidogrel belongs to the Antiplatelet Agent class and Warfarin belongs to the Vitamin K Antagonist (Anticoagulant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both medicines work to prevent blood clots, but they do it in different ways. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Clopidogrel has 19 total documented interactions on file in this dataset, and Warfarin has 163. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor yourself closely for any unusual bleeding or bruising. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Clopidogrel or Warfarin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.