Trazodone and Selegiline Interaction
Drug interaction information between Trazodone and Selegiline.
Trazodone and Selegiline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Trazodone and Selegiline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both raise serotonin levels, and taking them at the same time increases the risk of a toxic reaction.
FDA Label Information
Examples: isocarboxazid, moclobemide, phenelzine, selegiline, tranylcypromine Other Serotonergic Drugs Clinical Impact: The concomitant use of serotonergic drugs including trazodone and other serotonergic drugs increases the risk of serotonin syndrome.
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Tramadol minor
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Vortioxetine moderate
Frequently Asked Questions
What SPL severity band is on file for Trazodone + Selegiline?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trazodone has 40 labeled pairs on file vs Selegiline's 9. In the moderate band specifically: Trazodone has 4 (also Aspirin, Phenelzine, Tranylcypromine); Selegiline has 6 (also Desvenlafaxine, Levomilnacipran, Mirtazapine, Paroxetine).
What mechanism field is on file for Trazodone and Selegiline?
These medications both raise serotonin levels, and taking them at the same time increases the risk of a toxic reaction.
Trazodone carries more major-labeled pairs than Selegiline
SPL source-record counts only. This page's band is moderate · classes on file: Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)); Selegiline (Selective MAO-B Inhibitor).
Trazodone has 1 major-labeled pair vs Selegiline's 0. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 35 minor · 40 total
- Other moderate peers for Trazodone
- Aspirin
- Phenelzine
- Tranylcypromine
0 major · 6 moderate · 3 minor · 9 total
- Other moderate peers for Selegiline
- Desvenlafaxine
- Levomilnacipran
- Mirtazapine
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.