Trazodone and Tranylcypromine Interaction
Drug interaction information between Trazodone and Tranylcypromine.
Trazodone and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Trazodone and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can cause a harmful buildup of serotonin in your body.
FDA Label Information
Examples: isocarboxazid, moclobemide, phenelzine, selegiline, tranylcypromine Other Serotonergic Drugs Clinical Impact: The concomitant use of serotonergic drugs including trazodone and other serotonergic drugs increases the risk of serotonin syndrome.
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Selegiline moderate
- Tramadol minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Trazodone + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Trazodone's 40. In the moderate band specifically: Trazodone has 4 (also Aspirin, Phenelzine, Selegiline); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Trazodone and Tranylcypromine?
Using these drugs together can cause a harmful buildup of serotonin in your body.
Tranylcypromine carries more major-labeled pairs than Trazodone
SPL source-record counts only. This page's band is moderate · classes on file: Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Trazodone's 1. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 35 minor · 40 total
- Other moderate peers for Trazodone
- Aspirin
- Phenelzine
- Selegiline
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.