Trandolapril and Digoxin Interaction
Drug interaction information between Trandolapril and Digoxin.
Trandolapril and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trandolapril and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not affect how the body absorbs or gets rid of each other. There is no known significant interaction between them.
FDA Label Information
Other No clinically significant pharmacokinetic interaction has been found between trandolaprilat and food, cimetidine, digoxin, or furosemide.
Trandolapril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Amiloride moderate
- Furosemide minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Trandolapril + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Trandolapril's 8. In the minor band specifically: Trandolapril has 4 (also Furosemide, Warfarin, Cimetidine); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Trandolapril and Digoxin?
These drugs do not affect how the body absorbs or gets rid of each other. There is no known significant interaction between them.
Digoxin carries more major-labeled pairs than Trandolapril
SPL source-record counts only. This page's band is minor · classes on file: Trandolapril (ACE Inhibitor); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Trandolapril's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 4 minor · 8 total
- Other minor peers for Trandolapril
- Furosemide
- Warfarin
- Cimetidine
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.